Total Synthesis of bioactive Natrual Products
Our group has made significant strides in synthesizing complex and biologically active natural products and their derivatives through innovative strategies and the discovery of new chemical methodologies. Documented in 247 publications, our research merges expertise in target-oriented synthesis with an increasing emphasis on biological and drug discovery applications. Additionally, we have publ...
174.Regioselective Syntheses of 1,4- and 1,6-Dicarbonyl Compounds via Photoredox-Based Oxidative Heterocoupling of Enolsilanes with Oxygen as an Oxidant
A photoredox-based oxidative heterocoupling of enolsilanes to the corresponding 1,4- and 1,6-dicarbonyl compounds was developed by using Mes-Acr+BF4– as the photocatalyst, and oxygen was used as the oxidant. This newly developed chemistry adheres to the principles of atom economy, step economy, and redox economy, making it a concise and efficient method.
173.Total Synthesis of (+)−Haperforin G
(+)-Haperforin G was synthesizedin 20 steps from commerciallyavailable starting materials. A Co-catalyzed intramolecular Pauson-Khandreaction was used for stereoselective construction of cyclopentanonebearing an all-carbon quaternary stereogenic center at the bridge-headposition. Light-initiated photocatalysis was used for convergent andasymmetric cross-coupling of the unstabilized C(sp(3)) rad...
Research
Our group is interested in a program to develop synthetic strategies and methods with the aim of advancing the frontiers of the total syntheses of biologically important complex natural products. Typical endeavors include 1) exploration of the synthetic strategy of natural product based on photochemical reaction; 2) development of powerful reactions (such as Pauson-Khand reaction and Diels-Alde...